The policy brief discusses Circular Economy Business Models (CBM), gives several examples and considers the challenges and solutions facing policymakers. It makes a number of recommendations to regions to speed up the development of CBMs ‒ something this brief argues regions are in a good position to do ‒ and shares several good practices from Interreg Europe projects. It should be read in conjunction with the Interreg webinar on CBMs webinar on Circular Economy Business Models. It also briefly sketches EU policies in this area and offers some practical funding and networking tips.