First2Run is a flagship project involving four companies and universities from Italy, UK and The Netherlands, demonstrating technical, economic and environmental sustainability on an industrial scale. This involves a first-of-kind value chain where low input and underutilized oil crops grown in arid and/or marginal lands and not in competition with food or feed, are exploited for the extraction of vegetable oils to be further converted into bio-monomers. These bionomers act like building blocks for high added value bioproducts, biolubricants, cosmetics, bioplastics, additives through the integration of chemical and biotechnological processes.